RNA Details
Disease Name
nephritis interstitia
Tissue
kidney
RNA Symbol
Arid2
RNA ID
ENSMUSG00000033237
RNA Type
lncrna
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
qPCR;
Target
NA
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
25743111
Title
Long Noncoding RNA Arid2-IR Is a Novel Therapeutic Target for Renal Inflammation
Year
2015
Function
"In vitro knockdown of Arid2-IR from tubular epithelial cells produced no effect on TGF-beta-induced Smad3 signaling and fibrosis but inhibited interleukin-1beta-stimulated NF-KB-dependent inflammatory response. In contrast, overexpression of Arid2-IR promoted interleukin-1beta-induced NF-KB signaling and inflammatory cytokine expression without alteration of TGF-beta-induced fibrotic response. Furthermore, treatment of obstructed kidney with Arid2-IR shRNA blunted NF-KB-driven renal inflammation without effect on TGF-beta/Smad3-mediated renal fibrosis."